Sulfur mustard (SM) is a severe vesicating agent. Recommended SM lesion treatment is symptomatic. Discussions with the medical community and a literature review indicated a need for an animal model with superficial (epidermis only) and superficial dermal (upper third of the dermis) injuries. Eight female Yorkshire-cross pigs weighing ~10 kg were used in a dose ranging study. Undiluted liquid SM (400 μL) was applied at each of six ventral abdominal sites with exposure times ranging from 15-30 s for superficial injuries and 1-16 min for superficial dermal injuries. Exposure times of 7 and 8 min were selected and evaluated in an additional 6 animals. Lesions were photographed, measured, and assessed for edema presence on Day 1 and Day 2 after SM exposure, after which animals were euthanatized and lesions excised for histopathology. In the dose ranging study, one-half of each lesion was processed to prepare hematoxylin and eosin (H&E) stained slides and the other half was frozen in liquid Freon for staining with neutral blue tetrazolium chloride (NBTC). Superficial lesions were characterized by a depth of injury of less than 0.1 mm (NBTC stain) and affected only the epidermis. Morphological findings included basal cell necrosis, endothelial cell damage, presence of intraepidermal pustules and neutrophil infiltrate, minimal to mild dermal congestion and hemorrhage, and occasional necrosis of follicles to the isthmus. Exposures less than 1 min tended to produce lesions with a patchy distribution and focal extensions through the epidermis. Dermal injury (minimal to mild dermal congestion, minimal dermal coagulation, and/or minimal dermal hemorrhage) was observed subjacent to basal cell necrosis. Superficial dermal injury (upper1/3 of the dermis) occurred at sites exposed for 1 to 8 min, and were characterized by a depth of injury of 0.15 to 0.4 mm (NBTC). Superficial dermal morphology included lesions described as superficial injuries and more frequent dermal elastosis, coagulation, and greater congestion (all scored as mild). Basal cell necrosis affected ≥ 40 percent of the exposed area on average for exposure times of 6 to 8 min, and ≥ 80 percent for exposure times greater than 10 min. Follicular necrosis extended to the isthmus, but not the inferior segment. Dermal edema was not observed. Exposure times of 10 to 16 min produced a depth of injury >0.4 to 0.6 mm and necrosis involving follicles at the level of the infundibulum. Coagulation into the adipose tissue was present in sites exposed for greater than 12 min, and involved the panniculus muscle for exposures of 16 min. The dose-ranging study determined that use of the techniques established to produce SM-induced full-skin-thickness lesions did not produce uniform superficial (epidermis only) lesions. An exposure time of 8 min generated superficial dermal injuries on the ventral abdomen of weanling swine.