Cutaneous exposure to sulfur mustard is known to result in varying degrees of injury to epidermal cellular components, constituents of the basement membrane zone, and underlying connective and vascular tissues. The vesication phase of vapor sulfur mustard injury has been described, in part, by the immunohistochemical localization of proteins associated with the dermal/epidermal junction. Alterations to proteins comprising the hemidesmosomal plaque, the lamina lucida of the basement membrane zone, and anchoring filaments have been identified and are supported by morphological and ultrastructural studies. These immunohistochemical strategies can be used further to localize proteins known to be associated with re-epithelialization and dermal repair in an effort to describe the progression of wound healing following sulfur mustard injury and to evaluate the success of clinical strategies designed to aid in cutaneous repair. More specifically, our laboratory has tested 71 human antibodies for cross reactivity in weanling pig skin. Of those tested, 33 have proven useful for localizing the cellular and/or structural components associated with granulation tissue formation, neovascularization, basement membrane zone remodeling, and re-epithelialization.