UMDNJ-Rutgers University
CounterACT Research
Center of Excellence

Designing therapies to counteract chemical terrorism.

 

Jeffrey D. Laskin, Ph.D.

Professor and Chief of Toxicology
Environmental & Occupational Health Sciences Institute
UMDNJ - Robert Wood Johnson Medical School

Email: jlaskin@eohsi.rutgers.edu
Room: 446 EOHSI
Phone: 732-445-0176
Fax: 732-445-0119

Lab: 441 EOHSI

B.S. Chemistry and Biology, New York University
Ph.D. Pharmacology, SUNY at Buffalo, Roswell Park Cancer Institute
Postdoctoral, Cancer Biology, College of Physicians and Surgeons, Columbia University

Director, UMDNJ-Rutgers University CounterACT Center of Excellence

 

Research Interests:

Mechanisms of chemical toxicity, redox cycling, wound healing, regulation of keratinocyte growth, exposure to the sun and ultraviolet light, chemical carcinogenesis, lung and liver toxicity.

 

 

Recent Publications:

Gray JP, Heck DE, Mishin V, Smith PJS, Hong JY, Thiruchelvam M, Cory-Slechta DA, Laskin DL, and Laskin JD. Paraquat increases cyanide-insensitive respiration in murine lung epithelial cells by activating an NAD(P)H: Paraquat Oxidoreductase: Identification of the enzyme as thioredoxin reductase. (2007) J Biol Chem, epub ahead of print. [abstract]

Dambach DM, Durham SK, Laskin JD, Laskin DL. Distinct roles of NF-kappaB p50 in the regulation of acetaminophen-induced inflammatory mediator production and hepatotoxicity. (2006) Toxicol Appl Pharmacol, 211 (2): 157-165. [abstract]

Martey CA, Vetrano AM, Whittemore MS, Mariano TM, Heck DE, Laskin DL, Heindel ND, Laskin JD. Inhibition of interferon-gamma signaling by a mercurio-substituted dihydropsoralen in murine keratinocytes. (2005) Biochem Pharmacol, 70 (12): 1726-1734. [abstract]

Vetrano AM, Heck DE, Mariano TM, Mishin V, Laskin DL, Laskin JD. Characterization of the oxidase activity in mammalian catalase. (2005) J Biol chem, 280 (42): 35372-35381. [abstract]

Weinberger B, Hanna N, Laskin JD, Heck DE, Gardner CR, Gerecke DR, Laskin DL. Mechanisms mediating the biologic activity of synthetic proline, glycine, and hydroxyproline polypeptides in human neutrophils. (2005) Mediators Inflamm, 2005 (1): 31-38. [abstract]

Heck DE, Kagan VE, Shvedova AA, Laskin JD. An epigrammatic (abridged) recounting of the myriad tales of astonishing deeds and dire consequences pertaining to nitric oxide and reactive oxygen species in mitochondria with an ancillary missive concerning the origins of apoptosis. (2005) Toxicology, 208 (2): 259-271. [abstract]

Heck DE, Vetrano AM, Mariano TM, Laskin JD. UVB light stimulates production of reactive oxygen species: unexpected role for catalase. (2003) J Biol Chem, 278 (25): 22432-22436. [abstract]

Patents:

US patent #7,150,967,  December 19, 2006, Laskin JD, Martey C, Heindel ND, Whittemore M, and Heck DE (2006) Fluorescent tags for amino acid and nucleic acid analysis. University of Medicine & Dentistry of New Jersey (New Brunswick, NJ), Rutgers, the State University (New Brunswick, NJ), Lehigh University (Bethlehem, PA), Buckman Laboratories International, Inc. (Memphis, TN) [abstract]

US patent # 7,105,511, September 12, 2006, Laskin JD, Heindel N, Heck DE, Vetrano AM, Guillon C, and DeMatteo P (2006) Fluorescent fused-ring triazoles that inhibit cell proliferation and uses thereof. University of Medicine and Dentistry of New Jersey (New Brunswick, NJ), Rutgers, the State University (New Brunswick, NJ), Lehigh University (Bethlehem, PA) USA [abstract]

US patent # 7,015,022, March 21, 2006, Laskin JD, Vetrano AM, and Heck DE (2006) Mammalian catalase-dependent oxidation processes and methods for stimulating oxidative activities. University of Medicine & Dentistry of New Jersey (New Brunswick, NJ) [abstract]

 

Copyright © 2006 Joshua P. Gray